The Relationship between the Gastric Mucosal Defense and the Acid Secretion in Patients with Obstructive Jaundice

Hiroaki Omori

First Department of Surgery, Iwate Medical University School of Medicine

The present study was conducted to determine the relationship between the gastric mucosal defense and acid secretion before and after biliary drainage in patients with obstructive jaundice. Studies were carried out on 16 patients with normal endoscopic findings of the gastric mucosa, 18 obstructive jaundice patients without biliary drainage and 11 patients with biliary drainage. Endoscopic investigation included gastric mucosal blood flow (GMBF), potential difference (PD), prostaglandin E₂, F₂α (PGE₂, F₂α) and pH of the mucus lake (pH). In the normal group, GMBF of the body of the stomach was about 1.3 times higher than that of the angle and antrum, but in patients with jaundice, the GMBF in the body tended to be lower. The PD of each region in patients with jaundice tended to be lower than in the normal group. After biliary drainage, a tendency towards improvement in GMBF and PD, and towards a decrease in PGE₂ was seen. In conclusion, it is suggested that a decrease in PD and PGE₂, plays an important role in the occurrence of acute gastric mucosal lesion with obstructive jaundice.

Key words
obstructive jaundice, gastric mucosal blood flow, potential difference of the gastric mucosa, gastric mucosal prostaglandin, gastric pH

Reprint requests
Hiroaki Omori First Department of Surgery, Iwate Medical University School of Medicine
19-l Uchimaru, Morioka, 020 JAPAN

Accepted
April 11, 1990

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