Differences of DNA Ploidy Patterns and Expression of Epidermal Growth Factor in Varriant Sites of a Esophageal Carcinoma -Reports of Seven Cases

Shigeru Deguchi, Takayoshi Toda*, Syuji Tomita, Yushi Hamada, Norihiko Okushima, Yutaka Takaesu, Fasal A Muazzam, Yoshihiro Muto

First Department of Surgery, Ryukyu University, School of Medicine
*Clinical Laboratory, Ryukyu University Hospital

To study the intratumoral regional differences in DNA ploidy and the expression of epidermal growth factor (EGF) of esophageal carcinoma, multipre samples from different sites of a tumor each of seven patients were subjected to DNA anlaysis and immunohistochemical examination for EGF. Every patient showed intratumoral regional differences in DNA index and a marked regional differences (0.4 or more) were found in three patients. Intratumoral regional differences in DNA ploidy were obseved in five patients. Regarding EGF expressions, six patients showed regionally different degrees and the degree of EGF expression as closely related to the histological differentiation of the carcinoma. However, there was no certain relationship between DNA ploidy and EGF expression. The results suggest that esophageal carcinoma may constitute a feature of intratumoral regional polymorphism.

Key words
DNA analysis on a esophageal carcinoma, intra tumoral regional heterogeneity, expression of epidermal growth factor

Reprint requests
Shigeru Deguchi First Department of Surgery, Ryukyu University School of Medicine
207 Aza-Uehara, Nishiharamachi, Nakagamigun, 903-01 JAPAN

Accepted
April 11, 1990

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