A Case of Malignant Schwannoma of the Stomach

Goro Matsumiya, Yoshiro Oguchi, Takaharu Oue, Hirotsugu Fukuda, Nobuo Ogino, Akihiro Ochi, Yukio Oshita, Suzuo Kobayashi, Tetsuto Takao, Tetsumi Yamane*, Shoichi Katayama*

Department of Surgery and *Department of Pathology, Kure National Hospital

A 57-year-old woman was admitted with complaints of epigastralgia and jaundice. A common bile duct stone was detected, and an upper GI series revealed a submucosal tumor in the stomach. Cardiectomy, cholecystectomy, and choledocholithotomy were carried out. The tumor was 4.5×4.0×2.2 cm in size and it had an ulceration at the top. Histological examination including hematoxilin-eosin staining, positive S-100 protein staining, and negative actin staining led to the diagnosis of malignant schwannoma of the stomach. Malignant schwannoma of the stomach is rare, and this is only the 11th report of it Japan. Difficulty in differential diagnosis from a neurogenic or smooth muscle tumor, such as leiomyosarcoma, and the importance of immunohistochemical methods, such as S-100 protein staining, were emphasized. Because of poor prognosis due to hematogenous metastasis, early detection and treatment of the distant metastases are important.

Key words
malignant schwannoma of the stomach, immunohistochemical study, S-100 protein

Reprint requests
Goro Matsumiya Department of Surgery, Kure National Hospital
3-1 Aoyama, Kure, 737 JAPAN

Accepted
April 11, 1990

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