A Study of Esophageal Cancer with Synchronous or Metachronous Primary Malignant Neoplasms in Other Organs

Masakazu Yamamoto, Misao Yoshida, Yoko Murata, Masahiko Muroi, Toshihisa Ogawa, Kumiko Monma*, Nobuhiro Sakaki*

Department of Surgery, Tokyo Metropolitan Komagome Hospital
*Department of Internal Medicine, Tokyo Metropoliatn Komagome Hospital

We analyzed 421 cases of esophageal cancer treated (313 by esophagectomy) at the Department of Surgery, Tokyo Metropolitan Komagome Hospital between 1975 and July 1989. Of these, 51 patients (l2.1%) had primary neoplasms in other organs (synchronous in 26 [6.2%], metachronous in 25 [5.9%]). Gastric cancers were most frequently combined with esophageal cancers (25 cases; synchronous 15, metachronous 10) and 19 of these cases (76%) were early. Combination with head and neck cancers (16 cases; 3.8%) was the second most frequent, 10 of these cancers (62.5%) were diagnosed before detection of the esophgeal cancers. Esophageal cancers combined with multiple primary malignant neoplsms in other orgns were found in 5 (9.8%) of 51 patients, who were alive for 5 years after treatment of the first cancers. The incidence of second malignancies in other organs in patients between 5 and 7 years after esophagectomy (23.1%) was significantly higher than within 3 years (1.1%). Recently second primary malgnant neoplasms combined with esophageal cancers have been increasing in number, and we consider it important to work to understand the present condition in routine clinical work.

Key words
esophageal cancer, synchronous or metachronous primary malignant neoplasm

Reprint requests
Masakazu Yamamoto Department of Surgery, Tokyo Metropolitan Komagome Hospital
3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113 JAPAN

Accepted
October 7, 1990

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