Correlationship between c-erB2 Protein Expression and Clinical Outcome in Gastric Cancer

Yutaka Yonemura, Shigekazu Ohoyama, Itasu Ninomiya, Kazuo Kinoshita, Sachio Fushida, Hironobu Kimura, Takeo Kosaka, Akio Yamaguchi, Kouichi Miwa, Itsuo Miyazaki

Department of Surgery II, School of Medicine, Kanazawa University

The correlation of c-erbB-2 protein expression and clinicopathologic findings was studied in 150 gastric carcinomas. They were stained for c-erbB-2 protein by an immunohistochemical technique using a polyclonal antibody against c-erB-2 protein. No c-erbB-2 immunoreactivity could be found in the gastric epithelium. cerbB-2 protein was found in 26 (16.7%) of the 150 gastric carcinomas. Positive staining was associated with positive serosal invasion, and a positive nodal status of the patients, and with larger tumors (greater than 6 cm). In addition, there was a significant correlation between staining and outcome. These results show that c-erbB-2 protein-tissue status may possibly be a useful prognostic marker for patients with gastric carcinoma.

Key words
c-erbB-2, gastric carcinoma, malignancy of gastric carcinoma

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Yutaka Yonemuara Department of Surgery II, School of Medicine, Kanazawa University
13-1 Takara-machi, Kanazawa City, 920 JAPAN

Accepted
September 12, 1990

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