Preoperative Serum Immunosuppressive Acidic Protein Level in the Prognosis of Gastric Cancer

Junichi Sakamoto¹⁾, Hiroaki Nakazato¹⁾, Yasuo Ohashi²⁾, Satoshi Teramukai³⁾, Shigetoyo Sazi⁴⁾, Hiromi Tanemura⁴⁾, Tetsuya Toge⁵⁾, Yasuhiko Kurosu⁶⁾, Ken Morita⁶⁾, Nobuaki Kaibara⁷⁾, Norio Shimizu⁷⁾, Hisaaki Koie⁸⁾, Kunzo Orita⁹⁾, Kiyoshi Inokuchi¹⁰⁾

1) Department of Gastroenterological Surgery Aichi Cancer Center, 2) Department of Epidemiology and Biostatistics, School of Health Science, Faculty of Medicine, University of Tokyo, 3) University Hospital Computor Center, University of Tokyo Hospital, 4) Second Department of Surgery, Gifu University, 5) Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, 6) First Department of Surgery, Nihon University, 7) First Department of Surgery, Tottori University, 8) First Department of Surgery, Hirosaki University, 9) First Department of Surgery, Okayama University and l0) Department of Surgery, Saga Prefectural Kohseikan Hospital

To confirm the suggested Immunosuppressive Acidic Protein cut off level (580 µg/ml) that segregates the prognosis of gastric cancer on the basis of a multiinstitutional study, preoperative serum IAP and prognosis of 558 cases from 4 university hospitals were analyzed by using Cox's proportional hazard model. Five-year survivals of these gastric cancer patients were 65% in the low IAP group (<580 µg/ml) and 36% in the high IAP group (≥580 µg/ml) and a significant difference was detected by the longrank test (P<0.001). After adjusting for confounding factors such as histological invasiveness (s) and lymph node metastasis (n) by Cox's proportional hazard model, the relative risk for the high IAP group was 1.30 (P=0.088) in the total cases and was 1.49 (P=0.089) in curative resections, as compared with the low IAP group.

Key words
preoperative immunosuppressive acidic protein, gastric cancer, Cox's proportional hazard model

Reprint requests
Junichi Sakamoto Department of Gastroenterological Surgery, Aichi Cancer Center
1-1 Kanokoden, Chikusa-ku, Nagoya, 464 JAPAN

Accepted
November 19, 1990

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