A Study of Blood Coagulation and Fibrinolysis System in Experimental Acute Pancreatitis -With Special Reference to the Effect of Antiprotease Inhibitor-

Sin-Soo Ha, Katsusuke Satake, Akihito Hiura, Hideki Nishiwaki, Kaoru Umeyama

First Department of Surgery, Osaka City University Medical School

Dogs in which was experimental acute pancreatitis, induced by intraductal injection of an autologous bile and trypsin mixture were examined for changes in blood coagulation and the effect of new protease inhibitors (FUT-175 and E-3123) on blood coagulation in this condition were also investigated. The macroscopic finding in the pancreas five hours after the induction of an autologous bile and trypsin mixture was hemorrhagic necrotizing pancreatitis in all three groups. During acute pancreatitis, decreased levels of platelet counts, fibrinogen, AT-III and α₂-PI were observed and the prolongation of PTT, and increased FDP, FPA and Bβ 15-42 were also found. These results show that coagulation abnormalities during acute pancreatitis are similar to the findings of disseminated intravascular coagulation. Treatment with FUT-175 (3 µg/kg/min) improved abnormalities considerably but no marked improvement in abnormalities was observed after treatment with E-3123 (3 µg/kg/min). These results indicate that FUT-175 is to be of benefit in the treatment of coagulation abnormalities during acute pancreatitis of dogs.

Key words
experimental acute pancreatitis, coagulo-hemolytic abnormalities, protease inhibitors

Reprint requests
Sin-Soo Ha First Department of Surgery, Osaka University Medical School
1-5-7 Asahi-machi, Abeno-ku, Osaka, 545 JAPAN

Accepted
December 12, 1990

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