Changes of Blood Sugar and Pancreatic Hormone During Dibutyryl Cyclic Adenosine Monophosphate Load in Experimental Obstructive Jaundice in Dog

Junichi Komiya

Second Department of Surgery, Gunma University School of Medicine (Director: Prof. Masaru Izuo)

In order to investigate abnormalities of carbohydrate metabolism and pancreatic endocrine function in obstructive jaundice, the profile of changes in blood glucose, insulin and glucagon in response to DB-cAMP loading (group 1: 3 mg/kg one-shot injection in portal vein, group 2: 0.2 mg/kg/min 2-hour continuous infusion in portal vein) were monitored in dogs with obstructive jaundice. The results showed an increase in blood glucose in response to DB-cAMP loading, but after ligation of the common bile duct this blood glucose elevation lessened as jaundice progressed. DB-cAMP loading gave rise to an increase in both peripheral blood and portal vein immunoreactive insulin (IRI), however, this IRI elevation response lessened as jaundice progressed. The early IRI response to DB-cAMP loading was preserved even when jaundice was present. Pre-DB-cAMP loading immunoreactive glucagon (IRG) values were higher during jaundice than before jaundice was induced. There was hardly any change in the IRG response to DB-cAMP loading before jaundice in group 1, and there was a slight decrease in group 2. On the other hand, there was an IRG elevation response resembling the paradoxical IRG response during the oral glucose tolerance test in the presence of jaundice.

Key words
obstructive jaundice, dibutyryl cyclic adenosine monophosphate, carbohydrate metabolism, insulin, glucagon

Reprint requests
Junichi Komiya Shimada Memorial Hospital
607-22 Fujioka, Fujioka-shi, 371 JAPAN

Accepted
February 13, 1991

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