Experience of Intraoperative Peritoneal Hyperthermia Combined with Cis-dichlorodiammine Platinum for Gastric Cancer with Serosal Invasion

Tomoko Umeda, Masaki Nakanishi, Jiro Ohsawa, Masahiko Nonaka, Makoto Tanaka, Hiroshi Oka, Yasunori Sawabe, Fumie Tanaka, Masaaki Shinoda, Masashi Kodama*

Department of Surgery, Murakami Memorial Hospital, Asahi University
*First Department of Surgery, Siga University of Medical Science

We performed intraoperative peritoneal hyperthermia with concomitant use of cis-dichloro diammine platinum (CDDP) in six patients with serous-infiltration-positive gastric cancer. Side-effects connected with this therapy, pharmacokinetics and clinical efficiency were evaluated. Following IPH with concurrent use of CDDP 25 to 100 mg/m², total blood concentrations of CDDP reached to 0.71 g/ml in average in 5 minutes after starting the therapy and a maximum of 1.5 g/ml in average. No serous complications were noted during and after the operation. Three patients including two with normal preoperative PSP levels who were loaded with more than 70 mg/m² of CDDP showed transient elevation of s-BUN and s-creatinin reaching a peak in postoperative one to two weeks. However, all the three cases recovered without developing renal failure. The dosage of CDDP which would not induce postoperative renal dysfunction was considered to be 70 mg/m². Five of the six patients excluding one who died from another disease are surviving without any recurrences of gastric cancer.

Key words
gastric cancer with serosal invasion, intraoperative peritoneal hyperthermia, cis-dichlorodiammine platinum

Reprint requests
Tomoko Umeda Department of Surgery, Murakami Memorial Hospital, Asahi University
3-24 Hashimoto-cho, Gifu, 500 JAPAN

Accepted
January 16, 1991

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