Analysis on Hepatic Recurrence in Colorectal Cancer with Resected Hepatic Metastases

Akio Yamaguchi, Hironobu Kimura, Yoshiyuki Kurosaka, Tetsuya Ishida, Genichi Nishimura, Masahiro Kanno, Takeo Kosaka, Yutaka Yonemura, Ryouhei lzumi, Kouichi Miwa, Itsuo Miyazaki

Department of Surgery II, School of Medicine, Kanazawa University

Patterns of recurrence were examined in 40 patients who had resected of hepatic metastases from colorectal cancer. Twenty-five patients (62.5%) of these patients have had recurrence and 42.5% percent have had recurrence in the liver after hepatectomy. The hepatic recurrence rates did not correlate with the lobar distribution of metastases, number of lesions or surgical methods. As the size of the largest, tumors of over 5 cm were at an increases risk of having a recurrence in the residual liver. Positive pathologic margins were related to hepatic recurrence. The hepatic recurrence rate of aneuploid tumor was significantly higher than rate for diploid tumors. Eight patients received chemotherapy intrahepatically via a hepatic arterial catheter in selecting drugs by SDI test. The hepatic recurrence rate of patients with hepatic infusion chemotherapy was 25 percent, which was lower than the rate of 46.9 percent for ones without hepatic chemotherapy. The use of the SDI test will aid in selecting drugs for the prevention of hepatic recurrence after hepatectomy.

Key words
colorectal cancer, resection of liver metastases, hepatic recurrence, DNA ploidy pattern, SDI test

Reprint requests
Akio Yamaguchi The Department of Surgery II, Kanazawa University School of Medicine
13-1 Takara-machi, Kanazawa 920 JAPAN

Accepted
February 13, 1991

To read the PDF file you will need Abobe Reader installed on your computer.