Study on Hepatocellular Carcinomas with Extrahepatic Malignancies

Atsuyoshi Onitsuka, Naoki Yamada, Hironori Arakawa¹⁾, Yutaka Ozeki²⁾, Akitsugu Hino³⁾, Tatsumi Iida, Shoshi Senga, Kei Watanabe, Masatomo Hayashi, Hajime Hirose⁴⁾

1) Department of Surgery, Kaizu Medical Association Hospital
2) Department of Surgery, National Tosei Hospital
3) Department of Surgery, Gero Prefectural Hospital
4) First Department of Surgery, Gifu University School of Medicine

In 108 patients with hepatocellular carcinoma (HCC), 8 (7.4%) had extrahepatic malignancies. Seven had synchronous multiple primary malignancies and one had a metachronous cancer. Gastric cancer was the most common malignancy combined with HCC. It was considered that the upper gastrointestinal series was necessary for the patient with HCC. The frequency of liver cirrhosis was 62.5% in the patients with multiple primary cancers (n=8) and 91% in those with non-multiple primary cancers (n=100) (p<0.05). Retention rate of indocyanine green was 13.9±6.6% and 22.9±13.0% respectively (p<0.05). The frequency of positive HBsAg was 0% and 29% respectively. It was suggested that factors different from those of the ordinary HCC participate in multiple primary cancers.

Key words
hepatoma, hepatocellular carcinoma, double cancer

Reprint requests
Atsuyoshi Onitsuka Department of Surgery, Kaizu Medical Association Hospital
656-16 Fukue, Kaizu, Gifu, 503-06 JAPAN

Accepted
February 13, 1991

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