A Case of Mucin-producing Cholangiocarcinoma with Cystic Dilatation of the Intrahepatic Bile Duct

Michinori Murayama, Kazuo Hatsuse, Akira Komiyama, Shoetsu Tamakuma, Shintaro Terahata*

First Department of Surgery, National Defense Medical College
*Clinical Laboratory, National Defense Medical College Hospital

We experienced a case of mucin-producing cholangiocarcinoma with cystic dilatation of the intrahepatic bile duct. A 68-year-old woman who complained of right back pain was diagnosed as having choledocholithiasis and underwent cholecystectomy and choledochotomy. Mucin flowed out from the choledochotomy. She discharged because outflow of mucin decreased and malignancy was not found. In the following examination, serum DU-PAN-2 was found to be abnormally increased and cystic lesion was found in the left hepatic lobe. On the second operation, cytological study of the aspirate from the cystic lesion showed malignancy. Left hepatic lobectomy was performed under the diagnosis of mucin-producing cholangiocarcinoma. In the Japanese literature, 33 cases of the disease have been described and it is relative rare. The prognosis is thought to be better than that for common cholangiocarcinoma. However the cases of metastasis and invasion suggest the need for close follow-up.

Key words
mucin-producing cholangiocarcinoma

Reprint requests
Michinori Murayama First Department of Surgery, National Defense Medical College
3-2 Namiki, Tokorozawa, 359 JAPAN

Accepted
February 13, 1991

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