A Case Report of Anal Carcinoma Associated with Perianal Pagetoid Lesion

Michiaki Kudoh, Hiroshi Koitabashi, Kentaro Takebe, Kazuyuki Ohsaki, Takahiro Kojima, Ryoji Katoh, Seiichi Takenoshita, Yukio Nagamatchi

First Department of Surgery, Gunma University School of Medicine

Anal carcinoma associated with a perianal pagetoid lesion is extremely rare, and only nine cases including ours have been reported in Japan. On October 8 ,1989, a 74-year-old man was hospitalized in Gunma University Hospital with chief complaints of anal pain and tumor. Biopsy of the perianal skin revealed a pagetoid lesion and the left inguinal lymph nodes showed metastases. The patient was operated on November 29. Abdominoperineal excision of the rectum and dissection on part of the inguinal lymph nodes were performed. In addition to the operation, the patient was treated by postoperative radiotherapy. Histological diagnosis of the lesion was adenocarcinoma with pagetoid phenomenon originating in the sweat gland of the skin. Histochemically the cancer cells were PAS- and Alcian blue-positive.

Key words
extramammary Paget's disease, anal carcinoma, sweat gland carcinoma

Reprint requests
Michiaki Kudoh First Department of Surgery, Gunma University School of Medicine
3-39-15 Showa-machi, Maebashi, 371 JAPAN

Accepted
February 13, 1991

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