An Experimental Study of the Effects of Bile in the Stomach on Hypergastrinemia Following Selective Proximal Vagotomy

Hideki Kawasaki, Daisuke Wada, Nobuhiko Komi

The First Department of Surgery, School of Medicine, The University of Tokushima

The effects of bile in the stomach on hypergastrinemia following selective proximal vagotomy (SPV) was investigated in a canine experimental model. Twelve weeks after the operation, peripheral plasma gastrin (IRG) and somatostatin (SRIF) responses to a test meal in the bile-exposed group were lower than those in the control group. Both integrated IRG and SRIF responses were significantly lower in the bile-exposed group (8.98±2.27, and 7.14±1.62 ng·120 min/ml, respectively) than in the control group (15.26±2.97, and 11.87±2.71 ng·120 min/ml). Immunohistochemical staining revealed significantly decreased G and D cell populations in the antral mucosa of the bile-exposed group (30.5±3.9 and 22.1±1.9 cells/mm, respectively) compared with those of the control group (47.4±6.6 and 26.9±2.1 cells/min). These results indicate that bile in the stomach may decrease the G cell population and consequently inhibit hypergastrinemia following SPV. In addition, marked superficial gastritis with redness and petechie was seen in the antral mucosa of the bile-exposed group, which may be one cause of gastric ulceration following SPV.

Key words
hypergastrinemia following selective proximal vagotomy, plasma gastrin and somatostatin responses to test meal, G and D cell populations in the antral mucosa, bile reflux gastritis

Reprint requests
Hideki Kawasaki The First Department of Surgery, School of Medicine, The University of Tokushima
3-18-15 Kuramoto-cho, Tokushima, 770 JAPAN

Accepted
April 17, 1991

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