Assessment of a Hepatic Microsomal Functional Mass by Aminopyrine Breath Test after Partial Hepatectomy in Rats nrith CC1₄-induced Liver Injury

Hirotake Sugasawa, Masaru Miyazaki, Katsuji Okui

First Department of Surgery School of Medicine, Chiba University

In CC1₄-induced liver injury of rats, a hepatic microsomal functional mass measured by the ¹⁴C-aminopyrine breath test (ABT) was assessed, following 40% partial hepatectomy, and hepatic protein synthesis was also measured. The CC1₄ group had lower ABT values than the normal group, but the difference was not significance. After 40% partial hepatectomy, the ABT values decreased in the CC1₄ group more than in the normal group (p<0.05), and the return to the normal values was retarded in the CC1₄ group, survivors after 40% partial hepatectomy had higher ABT values (68±29%) preoperatively than that of deaths (16.9±2.7%). The difference was significance (p<0.05). Hepatic protein synthesis in the CC1₄ group was 3.6-fold greater than that in the normal group and was inversely correlated with the values of ABT (r=0.881 p<0.001). However there was no difference in hepatic protein content between the two groups. In conclusion, ABT is a good indicator of hepatic functional reserve in CC1₄-induced liver injury. Enhancement of hepatic protein synthesis would induce depression of the hepatic functional reserve measured by ABT.

Key words
CC1₄-induced liver injury aminopyrine breath test, hepatic protein synthesis, partial hepatectomy, hepatic microsomal functional mass

Reprint requests
Masaru Miyazaki First Department of Surgery, School of Medicine, Chiba University
1-8-1 Inohana, Chiba, 280 JAPAN

Accepted
April 17, 1991

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