An Experimental Study about the Dosage and the Number for an Adequate Repetitive Portal Administration of an Anticancer Drug as a Liver Metastatic Prophylaxia

Hiroshi Nakagomi

Second Department of Surgery, Yamanashi Medical College

We made a metastatic liver tumor model by injecting VX2 tumor cells into the portal vein of a rabbit. We then examined the suppressive effect of Adriamycin against liver metastasis, when administered through the portal vein in an adequate dose determined by a pharmacokinetic study. The minimum effective ADR concentration was determined in a sensitivity test using cultured VX2 tumor cells. And the pharmacokinetics of portal and systemic administration was analyzed with doses of 0.2, 0.4 and 0.8 mg/kg of body weight. The liver extraction ratio was higher with the smaller doses, but satisfactory liver concentration over the minimum effective concentration was achieved with a dose of 0.4 mg/kg. Complete suppression of liver metastasis was achieved by administering ADR 7 times at a dose of 0.4 mg/kg.

Key words
repetitive portal administration adriamycin, VX2 tumor, liver metastasis, optimal dose of adriamicin

Reprint requests
Hiroshi Nakagomi Yamanashi Medical College
1110 Shimokata, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38 JAPAN

Accepted
June 5, 1991

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