Combination Assay of Alpha-fetoprotein, Protein Induced by Vitamin K Absence or Antagonist-II and KMO1 for the Diagnosis of Hepatocellular Carcinoma

Tomoki Ueda, Makoto Usami, Ichiro Yasuda, Mitsutoshi Ogino, Hiroshi Kasahara, Harumasa Ohyanagi, Yoichi Saito

First Department of Surgery, Kobe University School of Medicine

Blood levels of PIVKA-II, KMO1 and AFP were measured and evaluated in 70 patients including 35 with hepatocellular carcinoma (HCC), 18 with liver cirrhosis and 6 with extrahepatic disease. The sensitivity and specificity were 40.4% and 97.1% for PIVKA-II, 51.4% and 71.4% for KMO1 and 65.7% and 91.4% for AFP respectively. There were no statistical significant correlations among the tumor markers, showing that each marker is independent. The combination assay of PIVKA-II, KMO1 and AFP was evaluated for screening HCC cases. The sensitivity was improved to 85.7% for HCC cases and to 82.4% for cases of resectable HCC. It was concluded that measurement of PIVKA-II, KMO1, AFP and of the combination of these markers is useful for the diagnosis of HCC.

Key words
alpha-fetoprotein, protein induced by vitamin K absence or antagonist-II, KMO1, screening test for hepatocellular carcinoma

Reprint requests
Tomoki Ueda First Department of Surgery, Kobe University School of Medicine
7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650 JAPAN

Accepted
July 3, 1991

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