Intraoperative Peritoneal Hyperthemia to the Gastric Cancer with Serosal Invasion

Yasunori Sawabe, Masaki Nakanishi, Jiro Ohsawa, Masahiko Nonaka, Hiroshi Oka, Fumie Tanaka, Satoshi Murata, Masaaki Shinoda

Department of Surgery, Asahi University, Murakami Memorial Hospital

We developed a method of intraoperative peritoneal hyperthemia (IPH) along with cisplatin acompanied with adjuvant immuno-chemotherapy to prevent peritoneal recurrence and to improve the prognosis of gastric cancer with serosal invasion and used the treatment for 21 patients. As a result, although the period of observation is still short, at most one year and seven months, there have been no deaths from peritoneal recurrence of gastric cancer in the IPH-treatd group. The survival rate for the IPH-treated group was significantly higher than that for the control group (p<0.05). The nine-months survival rate for the IPH-treated group (n=19) was 88.0%, whereas that for the control group (n=82) was 66.1%. Moreover, for Borrmann 4 type gastric cancer the survival rate for the IPH-treated group was significantly higher than that for the control group at p<0.001. The one-year and seven-months survival rate for the IPH-treated group (n=6) was 100%, whereas for the control group (n=22) was 24.9%. These results suggested that IPH is an effective treatment for gastric cancer with serosal invasion to prevent peritoneal recurrence.

Key words
intraoperative peritoneal hyperthermia, gastric cancer with serosal invasion, survival of gastric cancer patients

Reprint requests
Yasunori Sawabe Second Department of Surgery, Kyoto Prefectural University of Medicine
Hirokoji-agaru, Kawaramachi, Kamigyou-ku, Kyoto, 602 JAPAN

Accepted
September 4, 1991

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