Prediction of Hepatic Metastasis after Resection of Colorectal Carcinoma -From the Veiwpoint of Pathologic Features, c-erbB-2 Oncoprotein Expression and Nuclear DNA Content-

Kazuyoshi Ohmori, Junichi Uchino, Yukifumi Kondou, Yuji Sawaguchi, Hiroshi Shiroto, Hiroyuki Masuko, Shirou Nakano, Shyouhei Ohsawa, Masao Kondou, Osamu Nishida, Fumio Sano

First Department of Surgery, Hokkaido University School of Medicine

In 45 cases of colorectal carcinoma without hepatic metastasis, and 29 cases with synchronous and 16 cases with metachronous hepatic metastasis, the risk of hepatic metastasis from colorectal carcinoma was investigated by determining pathologic features, c-erbB-2 histochemical staining and nuclear DNA content. There was a correlation between synchronous hepatic metastasis and the depth of invasion, lymph node metastasis, involvement in small vessels (ly, v), histological stage, aneuploidy, and c-erbB-2 expression. There was a close correlation between metachronous hepatic metastasis and involvement in the small vessels and c-erbB-2 expression (p<0.01). These three factors appeared to be important predictors of hepatic metastasis after resection of colorectal carcinoma. On the other hand, there was no correlation between DNA ploidy pattern and involvement in small vessels, and because six of eleven cases with metachronous hepatic metastasis which did not have vascular invasion were aneuploidy. The findings suggests that the DNA ploidy pattern may develop the capacity to predict hepatic metastasis.

Key words
colorectal carcinoma, prediction of liver metastasis, c-erbB-2 oncoprotein, DNA ploidy pattern

Reprint requests
Kazuyoshi Ohmori First Department of Surgery, Hokkaido University School of Medicine
N-15, W-7, Kita-ku, Sapporo, 060 JAPAN

Accepted
September 4, 1991

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