Augmentation of Natural Killer Activity after Peritumoral Administration of OK-4 32 In Rectal Cancers

Yutaka Ogata, Hiroharu Isomoto, Kazuo Shirouzu, Yasumi Araki, Kiichiro Nakgawa, Teruo Kakegawa

The First Department of Surgery, Kurume University School of Medicine

OK-432 was administered preoperatively into the peritumoral tissues of 23 patients with rectal cancer. Natural killer (NK) activity of lymphocytes was isolated from peripheral blood, portal vein blood, and tumorous lesions, and the regional lymph nodes were measured by ⁵¹Cr release assay. There was no effect on peripheral blood lymphocytes (PBL) or lymph node lymphocytes (LNL) with the administration of OK432. NK activity of tumor infiltrated lymphocytes (TIL) was increased in half the cases after the administration of OK-432. NK activity of portal vein blood lymphocytes (PVL) was higher than that of PBL following OK-432 administration. The cases which showed high NK activity on TIL also showed high activity on PVL. The above results suggested that peritumoral administration caused increases in both TIL and PVL activity. Therefore, the preoperative injection of OK-432 to the peritumoral region in rectal cancer patient could be effective as preoperative adjuvant therapy, particularly for the inhibition of liver metastasis.

Key words
peritumoral administration of OK-432, natural killer activty of portal vein blood lymphocytes, natural killer activty of peripheral blood lymphocytes, rectal cancer

Reprint requests
Yutaka Ogata The First Department of Surgery, Kurume University School of Medicine
67 Asahi-machi, Kurume city, 830 JAPAN

Accepted
September 4, 1991

To read the PDF file you will need Abobe Reader installed on your computer.