A Remarkable Effect of Pre-operative Cancer Chemotherapy in a Case of Borrmann 4 Type Gastric Cancer with Massive Ascites

Takao Suzuki, Hidehiko Kashiwabara, Tadashi Hachisu, Kouichiro Oomori, Kaoru Sakamoto, Hotaka Amano, Takeo Yokoyama

Department of Surgery, Sakura National Hospital

A 55-year-old woman was admitted to the hospital because of abdominal distension. We made a diagnosis of Borrmann 4 type advanced gastric cancer with peritoneal dissemination by computed tomography and upper gastrointestinal series, and decided that it was inoperable. Although the white blood cell count was down to 2400/mm³ at admission, she was given a combination of oral administration of 5-FU, 200 mg/day, and intraperitoneal administration of cisplatin, 100 mg, followed by another combination therapy regimen consisting of intravenous administration of cisplatin, 100 mg, etoposide, 225 mg and 5-FU, 2250 mg. After this treatment, the massive ascites disappeared and the gastric lesion was improved with a slight decrease in white blood cell count. Total gastrecotmy was performed after improvement of the her general condition, and histopathological findings of the resected specimen revealed that our pre-operative chemotherapy was effective.

Key words
gastric cancer, pre-operative cancer chemotherapy, Cis-platinum

Reprint requests
Takao Suzuki The Second Department of Surgery, Chiba University School of Medicine
1-8-1 Inohana, Chiba, 280 JAPAN

Accepted
September 4, 1991

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