Histological Grade of Malignancy of the Recurrent Early Gastric Cancer after Curative Resection

Yoshihiro Saito, Kenichi Shiiba, Nobuo Ebina, Seiki Matsuno, Akio Ouchi*

First Department of Surgery, Tohoku University School of Medicine
*Department of Surgery, Tohoku Rosai Hospital

The records of 325 patients with early gastric cancer who had undergone curative resection during the previous 12 years were clinico-pathologically analyzed. Among them, 14 (4.3%) died of cancer recurrence. In the recurrent group, moderately differentiated tubular adenocarcionoma (tub₂) and poorly differentiated adenocarcinoma (por) were more common than the other histological types. The histological grade of malignancy was investigated histologically after these two histological types were divided into three subtypes: the so-called pure type of tub₂ (pure-tub₂), the pure type of por (pure-por) and a mixture of types tub₂ and por (tub₂-por). The incidence of lymph node metastasis in the tub₂-por type (28.6%) was statistically higher than that of the pure-tub₂ type (9.7%) and the pure-por type (12.8%). Furthermore the incidence of cancer recurrence of type tub₂-por (21.4%) was more frequent than that of type pure-tub₂ (2.8%) and type pure-por (2.1%). In conclusion, the mixture of types tub₂ and por, the socalled tub₂-por type was considered a higher grade of malignancy.

Key words
early gastric cancer, recurrence after curative resection, histological subtype of gastric cancer, histological grade of malignancy

Reprint requests
Yoshihiro Saito First Department of Surgery, Tohoku University School of Medicine
1-1 Seiryomachi, Aobaku, Sendai, 980 JAPAN

Accepted
October 9, 1991

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