Analysis of Portal and Peripheral Blood Levels of Carcinoembryonic Antigen, CA19-9, CA125 Tumor Associated Antigens in Patients with Colorectal Cancer

Kazuhiko Yoshida, Hiroaki Tanabe, Tatsuro Nakagawa, Toshiyuki Yoda, Sadao Anazawa, Kenji Sakurai

First Department of Surgery, The Jikei University School of Medicine

Synchronous serum specimens from the systemic and mesenteric circulation of 16 patients with colorectal cancer were assayed for the levels of carcinoembryonic antigen and CA19-9 and CA125 tumor-associated antigens. The hematocrit levels of draining vein were highly correlated with those of peripheral vein level (r²=0.90), and the dilution effect was noted (x-coef.=0.89). Draining vein levels of CEA, CA19-9, and CA125 were highly correlated with the peripheral vein levels (r²=0.91, 0.96, 0.81). These findings suggest that peripheral concentrations of these antigens are in equilibrium with shedding from tumors and that hepatic clearance of a single pass does not significantly alter the peripheral concentration.

Key words
carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 125, colorectal cancer

Reprint requests
Kazuhiko Yoshida First Department of Surgery, The Jikei University School of Medicine JAPAN

Accepted
October 9, 1991

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