Experimental Study on the Effect of Prostaglandin, E₁ on Decreased Hepatic Tissue Blood Flow during Operation

Yoshio Arai, Yoshihiro Asanuma, Hiroshi Nanjo, Tsutomu Sato, Yujiro Kato, Susumu Omokawa, Kenji Koyama

First Department of Surgery, Akita University School of Medicine

This study aimed to evaluate the effect of Prostaglandin (PG) E₁ on decreased hepatic tissue blood flow during operation. Twenty one dogs were divided into 2 groups; namely hepatic arterial low flow state group and portal venous low flow state group. Each blood flow was regulated to 0% or 50% by roller pump. Portal venous flow (PVF) and hepatic arterial flow (HAF) were measured using ultrasonic transit time flow meter, and tissue blood flow of the liver (TBF) was measured with electrolytic regional flow meter with or without continuous infusion of PGE₁. Without PGE₁ infusion, HAF was significantly increased to 161% after portal venous occlusion, but PVF was unchanged after hepatic arterial occlusion. TBF was markedly decreased to nearly 70% under HA or PV occlusion. On the contrary, in PGE₁ group, HAF and PVF were increased to 172% and 110%, respectively, and TBF was maintained at 82∼88% under HA or PV occlusion. Continuous infusion of PGE₁ can improve the decreased hepatic tissue blood flow during operation.

Key words
hepatic arterial flow, portal venous flow, tissue blood flow of the liver, regulation of hepatic blood flow, prostaglandin E₁

Reprint requests
Kenji Koyama First Department of Surgery, Akita University School of Medicine
1-1-1 Hondo, Akita, 010 JAPAN

Accepted
November 20, 1991

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