Serum Gastrin Response to Parathyroidectomy for Multiple Endocrine Neoplasia Type I and Primary Hyperparathyroidism

Harutsugu Sodeyama, Takai Kuroda, Shinya Kobayashi, Makoto Komatsu, Futoshi Iida

Department of Surgery, Shinshu University School of Medicine

In 2 patients with multiple endocrine neoplasia type I (MEN type I) and 10 patients with primary hyperparathyroidism (HPT), serum gastrin response to parathyroidectomy and gastrin immunoreactivity of the surgically resected parathyroid were investigated. In the patients with MEN type I, serum gastrin levels were obviously decreased. In the 10 patients with HPT, serum gastrin levels were decreased in 7 patients after parathyroidectomy; the mean gastrin levels were 216.1±228.3 pg/ml before and 113.1±51.1 pg/ml after the operation. Gastrin immunoreactivity was detected in 1 of the patients with MEN type I and 6 of the patients with HPT. There was no correlation between gastrin immunoreactivity, histological type of the resected parathyroid and serum gastrin levels.

Key words
multiple endocrine neoplasia type I, primary hyperparathuroidism, gastrin

Reprint requests
Harutsugu Sodeyama Department of Surgery, Shinshu University School of Medicine
3-1-1 Asahi, Matsumoto, 390 JAPAN

Accepted
January 8, 1992

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