Effect of Nutritional Status on Early Response of Cytokine to Surgery

Tetsuji Fujita, Makoto Odaka, Miwako Matsumoto, Kenji Sakurai

First Department of Surgery, The Jikei University School of Medicine

Portal and peripheral venous blood samples were obtained simultaneously from 43 patients who underwent abdominal surgery, about two hours after the beginning of the operation, and cytokine levels were measurEd. In addition to linear regression analysis of different cytokine levels, the relationships between cytokine levels and preor postoperative levels of acute phase protein were determined. No significant correlation was found between IL-l and IL-6 levels is the peripheral venous blood, but the portal blood levels of IL-l were positively correlated with the portal blood levels of IL-6 (r=0.31, p<0.05). The preoperative values of the third component of complement were positively correlated with the portal blood levels of IL-6 (r=0.64, p<0.001), as well as with the portal blood levels of IL-l (r=0.35, p<0.05). Furthermore, serum CRP levels on the first postoperative day were positively correlated with the portal blood levels of IL-6 (r=0.47, p<0.01), as well as with the peripheral venous blood levels of IL-6 (r=0.41, p<0.02). These data suggest that the cytokine response to surgery is closely related to the preoperative nutritional status.

Key words
cytokine response to surgery, nutritional status, acute phase protein

Reprint requests
Tetsuji Fujita First Department of Surgery, The Jikei University School of Medicine
3-25-8 Nishishinbashi, Minatoku, Tokyo, 105 JAPAN

Accepted
July 6, 1992

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