Clinical and Pathological Study on Prognostic Factors after Hepatic Resection with Lipiodol-anticancer Drug Transcatheter Arterial Infusion Therapy for Hepatocellular Carcinoma

Akio Ishikawa, Katashi Fukao, Masaaki Ohtsuka, Yasuhiro Takase, Takeshi Todoroki, Kazuo Orii, Susumu Shibuya, Mutsumi Nozue, Kenji Yuzawa, Shinya Adachi, Fumio Chikamori, Katsuhisa Tsuji, Akira Osada, Hiroshi Ueda, Yuuji Yamamoto, Noriaki Kuramoto*, Yukishisa Saida*, Yuuji Itai*, Masayuki Nakano**, Yoji Iwasaki

Department of Surgery, Department of Radiology*, Institute of Clinical Medicine, University of Tsukuba
**The Research Center for Pathologic Fungi and Microbial Toxicoses, Chiba University

The records of 34 patients with hepatocellular carcinoma who underwent hepatic resection with pre- and postoperative Lipiodol transcatheter arterial infusion therapy (L-TAI), excluding noncurative resections, were reviewed. Various clinical and pathological features of these cases were evaluated by analysis of the cumulative disease-free survival rate to clarify the prognostic factors after hepatic resection. One-, three- and five-year diseasefree survival rates in this series were 91%,68% and 45%, respectively. Necrosis of over 80% detected by preoperative L-TAI in the tumor nodule, tumor diameter less five cm, histologicat absence of portal vein involvement and histological absence of tumor invasion to the tumor capsule were the most significant prognostic factors in patients who underwent hepatic resection. The five-year disease-free survival rates were 100% in patients with and without tumor invasion to the tumor capsule.

Key words
hepatocellular carcinoma, lipiodol transcatheter arterial infusion therapy, disease-free survival rate after hepatectomy, prognostic factors of hepatocellular carcinoma

Reprint requests
Akio Ishikawa Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
1-1-1 Tennoudai, Tsukuba, 305 JAPAN

Accepted
July 6, 1992

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