Clinicopathological Analysis of the Patients Who had Plural Hepatic Resections for Hepatocellular Carcinoma

Taichi Shuto, Hiroaki Kinoshita, Kazuhiro Hirohashi, Shoji Kubo, Ryutaro Iwasa, Daisuke Kubota, Kenichi Wakasa*, Takatsugu Yamamoto**, Masami Sakurai**

Second Department of Surgery, Osaka City University Medical School
*Department of Pathology, Osaka City University Hospital
**Second Department of Pathology, Osaka City University Medical School

Curative hepatic resections were performed in 263 patients with hepatocellular carcinoma (HCC) from l98l to 1991. As of December 1991, there was recurrence in 142 cases (54%), and a second resection was performed in 20 cases (14%), which were analyzed clinicopathologically. The mean time from the first resection to detection of a recurrence in these 20 patients was 875 days. ICGR15 tended to increase by the time of second operation, and the amount liver resected tended to decrease. The total size of the tumors removed during the second resection was smaller (p<0.05) but the number of the tumors tended to increase. In eight cases, the recurrence was in another lobe of the liver. It was difficult to classify the 20 recurrences as involving intrahepatic metastasis or multicentric occurrence. In these 20 patients, a second resection was an effective treatment for recurrences of HCC. but for long-term survival, the mechanisms of recurrence must be identified.

Key words
recurrence of resected hepatocellular carcinoma, second resection of hepatocellular carcinoma, intrahepatic metastasis of hepatocellular carcinoma, multicentric occurrence of hepatocellular carcinoma

Reprint requests
Taichi Shuto Second Department of Surgery, Osaka City University Medical School
1-5-7 Asahi, Abeno-ku, Osaka, 545 JAPAN

Accepted
September 9, 1992

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