A Case Report of Lieomyoblastoma of Stomach

Masahiro Samizo, Takeshi Nakamura, Yoshiki Tabuchi*, Kentaro Kawasaki, Yutaka Hamabe, Michio Katoh, Yoichi Saitoh

First Department of Surgery, Kobe University School of Medicine
*School of Allied Medical Sciences, Kobe University

We recentry encountered a case of a 50-year-old man who complained of an abdominal mass. Preoperatively diagnosed as having gastric sarcoma invading the left hepatic lobe, the patient underwent total gastrectomy and lateral segmentectomy of the left heaptic lobe. Histological examination of removal tissue revealed proliferation of spindle-shaped and circular tumor cells as well as focal proliferation of perinuclear vacuolated cells and epithelial cells with an eosinophilic cell body. Leiomyoblastoma is usually regarded as low grade malignancy. However, several cases of this tumor showing metastasis or invasion to the surrounding tissues, like the present case, have been reported. Until now, mitotic rate, tumor size, nuclear DNA content, duration of the illness, and other variables have been reported as useful indices of the malignant grade of this tumor. Of these indices, the mitotic rate is regarded as useless according to some investigators. It also seems unlikely that the malignancy grade could have been determined by the nuclear DNA content alone, in the present case. Therefore it seems necessary to assess the grade of malignancy on the basis of a general evaluation of multiple variables. We recommend that this tumor be treated by the surgical procedures used for gastric cancer.

Key words
leiomyoblastoma of the stomach, DNA ploidy pattern, malignant signs

Reprint requests
Masahiro Samizo First Department of Surgery, Kobe University School of Medicine
7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650 JAPAN

Accepted
September 9, 1992

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