Value of the Level of Serum Creatine Phosphokinase for Early Diagnosis of Strangulation Ileus

Toshiya Maeda, Hideki Yuasa, Toshihiro Arimura, Shinichi Endou, Katsuya Akashi, Kazutaka Ashikawa

Critical Care Medicine, St. Marianna University, School of Medicine

One hundred forty-two patients (98 men and 44 women) with ileus were subjected to clinical study to establish a method of early diagnosis and treatment of strangulation ileus on the basis of serum creatine phosphokinase (CPK) levels during the 3 years between April 1987 and March 1990. The relation between findings at laparotomy and serum CPK levels was assessed. Serum CPK was 174.5±48.3 mu/ml in cases of strangulation ileus, 73.6±26.5 mu/ml in 23 cases of adhesive ileus and 54.1±7.5 mu/ml in 102 patients treated conservatively. A tendency toward correlation was observed between the serum CPK of the patients who underwent intestinal resection because of strangulation ileus and the severity of ischemic lesion of the intestinal tract. Thus it appeared that the level of serum CPK, which corresponded well with the results of diagnostic imaging and clinical findings, can be used as a parameter for early differential diagnosis.

Key words
acute abdomen, strangulation ileus, intestinal ischemia, creatine phosphokinase, creatine phosphokinase isoenzyme

Reprint requests
Toshiya Maeda The Second Department of Surgery, St. Marianna University School of Medicine
2-16-1 Sugao, Miyamae-ku, Kawasaki-shi, 216 JAPAN

Accepted
December 9, 1992

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