A Case of Cancer of the Thoracic Esophagus with Extended Lymph Node Involvement Well Controlled by Preoperative Chemotherapy

Eiji Sakamoto, Toshiki Matsubara, Mamoru Ueda, Sakae Okumura, Toshifusa Nakajima, Mitsumasa Nishi, Katsuhiro Inoue*

Department of Surgery and Cancer Chemotherapy*, Cancer Institute Hospital

The patient was a 64-year-old man who suffered from advanced esophageal cancer with extended mediastinal lymph node metastasis involving the bilateral main bronchi, left atrium and bilateral inferior pulmonary veins. He was treated by four cycles of continuous infusiona of a combination of cisplatin (75 mg/m²/day 1/q4w), mitomycin-C (10 mg/m²/day 1/q8w) and 5-FU (600 mg/m²/day 2-4/q4w). After chemotherapy, both of the primary and the metastatic lesions disappeared and a radical operation was successfully performed. Microscopically, the main lesion almost disappeared with only a small cancer nest remaining in the mucosa (Ef2), and lymph node metastasis completely disappeared (Ef3).

Key words
carcinoma of the thoracic esophagus, neoadjuvant chemotherapy

Reprint requests
Eiji Sakamoto Department of Surgery and Cancer Chemotherapy, Cancer Institute Hospital
1-37-1 Kamiikebukuro, Toshimaku, Tokyo, 170 JAPAN

Accepted
December 9, 1992

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