Analysis of Prognostic Factors for Hilar Bile Duct Cancer -Comparison between Ten 5-year-survivors and Fifty Eight Survivors Less Than 5-year-

Takeshi Todoroki, Toru Kawamoto, Mutsumi Nozue, Naoto Koike, Shuuji Kato, Kazuo Orii

Department of Surgery, Institute of Clinical Medicine, University of Tsukuba

Ten of 68 patients with hilar bile duct cancer who underwent tumor resection (13 for curative and 55 for noncurative resection) survived more than 5 years. The 68 patients were entered into a prognostic factor analysis using the log-rank test for Kaplan Meier's survival curves. The factors yielding significance after the log-rank test were examined to detect significant differences between the group surviving more than 5 years and the group surviving less than 5 years using the Fisher exact probability test. These analyses indicated that a patient would have a possibility of surviving more than 5 years provided that the patient underwent a curative resection (resection margins free from tumor microscopically) for papillary adenocarcinoma stage I or II (T1-2, N0, M0), i.e., a tumor which did not invade beyond perimuscular connective tissue, with no regional lymph node metastasis, located exactly at the major ductal confluence with minimum extension up to the right or left main hepatic duct, with no infiltration down to the middle common bile duct.

Key words
prognostic factors of hilar bile duct cancer

Reprint requests
Takeshi Todoroki Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
1-1-1 Tennoudai, Tsukuba-shi, 305 JAPAN

Accepted
December 9, 1992

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