The Management and Therapy of Postoperative Methicillin-resistant Staphylococcus aureus Enterocolitis -The Efficacy of Perioral or Enternal Administration of Vancomycin-

Shinya Kusachi, Yoshinobu Sumiyama, Kunihiko Kawai, Youichi Arima, Minoru Kurita, Yuichi Yoshida, Jiro Nagao

The Third Department of Surgery, Toho University

Eleven patients with postoperative methicillin-resistant Staphylococcus auleus (MRSA) enterocolitis were studied with regard to managements and antibiotic therapy with Vancomycin (VCM). The amount of diarrhea significantly decreased in the VCM-treated patients. The clinical effects of perioral or enteral administration of VCM and fluid restoration with fresh frozen plasma were good both diarrhea and respiration. Since MRSA remains in the intestine during the early stage of this disease, the enteral administration of VCM seemed to be very useful and had no sideeffects. Fluid restoration with fresh frozen plasma stabilizes the circulation and prevent pulmonary edema.

Key words
managements of postoperative MRSA enterocolitis, prophylaxis of postoperative MRSA enterocolitis, vancomycin

Reprint requests
Shinya Kusachi The Third Department of Surgery, Toho Ohashi Hospital
2-17-6 Ohashi, Meguroku, Tokyo, 153 JAPAN

Accepted
January 13, 1993

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