Clinicopathological and Mucin-histochemical Study of Gastric Cancer of the Residual Stomach and upper Portion of the Stomach

Hiroyuki Naitoh, Junsuke Shibata, Ryoji Kushima*, Akira Kawaguchi, Yutaka Eguchi, Masashi Kodama, Keiichi Yokoyama*, Takanori Hattori*

The First Department of Surgery and The First Department of Pathology*, Shiga University of Medical Science

The clinicopathological characteristics of gastric cancers of the residual stomach and upper portion of the stomach were comparatively studied with special reference to background mucosal changes. In the gastric cancers of the residual stomach, undifferentiated types were predominant, whereas in the gastric cancers of the upper portion, differentiated types were predominant. Macroscopically, the early gastric cancers of the residual stomach tended to be of an elevated type. On the other hand, the early gastric cancers of the upper portion tended to be depressed type or mixed type. Histologically, intestinal metaplasia was seen in background gastric mucosa in 75% of the gastric cancers of the residual stomach, and gastritis cystica polyposa was seen in 50%, whereas in the gastric cancers of the upper portion, the former was seen in 65% and the latter in only 8%. From mucin-histochemistry, it was shown that about 67% of gastric cancers of the residual stomach were of a gastric type, whereas 72% of the gastric cancers of the upper portion were of an intestinal type. These findings may indicate that the mechanism of cancerization is somehow different between gastric cancers of the residual stomach and of the upper portion, although the regions bearing each cancer were originally the same from an anatomical point of view.

Key words
gastric cancer of the residual stomach, gastric cancer in upper portion of the stomach, mucin-histochemistry, gastritis cystica polyposa, epithelial type of gastric cancer

Reprint requests
Hiroyuki Naitoh The First Department of Surgery, The Siga University of Medical Science
Seta Tsukiwa-cho, Otsu, 520-21 JAPAN

Accepted
April 14, 1993

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