A Case Report of Carcinosarcoma of the Stomach

Yasuji Kawabata, Takao Nakai, Kiyoshi Ooba, Takeo Okumura, Yutaka Matsuura, Yoshiki Miyazaki, Tadashi Itou, Ken Hujishiro, Takashi Takemura

Department of Surgery, Nagoya Ekisaikai Hospital

A 72-year-old man was admitted to our hospital with loss of appetite and anemia. Gastroscopy showed a Borrmann I type tumor in the antrum. Leiomyosarcoma was suggested from the biopsy specimens of the lesion. After admission, an emergency gastrectomy was performed because of massive gastric bleeding. Histological examination revealed carcinosarcoma of the stomach. Adenocarcinoma cells and undifferentiated tumor cells, which were not clearly determined as epithelial or non-epithelial, were found in the metastatic lymph node. Five months postoperatively the patient died of liver failure due to liver metastasis. Only adenocarcinoma was found in the metastatic lesion of the liver. Immunoperoxidase studies showed that the adenocarcinoma cells were strongly positive for CEA and EMA and were negative for desmin, vimentin and s-100 protein. In contrast, the cells in the sarcomatous portion were positive for desmin and vimentin and were negative for the epithelial marker. Only 20 cases of carcinosarcoma of the stomach (excluding collision tumor) have been reported in Japan.

Key words
carcinosarcoma of the stomach, immunohistological study, pseudosarcoma

Reprint requests
Yasuji Kawabata First Department of Surgery, Nagoya University School of Medicine
65 Turuma-cho, Showa-ku, Nagoya, 466 JAPAN

Accepted
April 14, 1993

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