An Atomic Bomb Survivor Patient with Multiple Carcinomas and Dysplasias of Small Intestine

Kazuyoshi Hoshino, Kazuo Kurayoshi, Toshihisa Kijima, Yasuhiro Nakamura, Akira Sugezawa, Masato Makino, Osamu Kimura, Nobuaki Kaibara

First Department of Surgery, Tottori University School of Medicine

A 66-year-old man who had been exposed to the atomic bomb explosion underwent surgery for the adhesive ileus. Borrmann type 2-like advanced cancer and two IIc-like dysplasias of the jejunum were found. Postoperative examination showed multiple IIc-like lesions of the duodenum and jejunum. Reoperation was performed, and the anal half of the duodenum and jejunum were resected. The resected specimen showed a IIa+IIc-like carcinoma at the third portion of the duodenum and 25 IIc-like dysplasias at the duodenum and jejunum. The DNA ploidy pattern of the cancer of the jejunum and duodenum was aneuploidy and the normal duodenal mucosa and most of the IIc-like dysplasias also showed aneuploidy. These findings suggested the atomic bomb explosion as a possible cause of the lesions.

Key words
multiple carcinomas and dysplasias of the small intestine, atomic bomb, DNA ploidy pattern

Reprint requests
Kazuyoshi Hoshino First Department of Surgery, Tottori University School of Medicine
36-1 Nishimachi, Yonago, 683 JAPAN

Accepted
April 14, 1993

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