A Case of Hepatocellular Adenoma Associated with Oral Contraceptive

Keiji Maruyama¹⁾, Kiyotsugu Yoshikawa³⁾, Mitsutaka Hashimoto³⁾, Hiroshi Takemoto³⁾, Akira Inoue³⁾, Akira Sugitani³⁾, Tomio Arai²⁾, Isamu Kino²⁾, Haruhiko Sugimura²⁾

Second Department of Surgery¹⁾ and First Department of Pathology²⁾, Hamamatsu University School of Medicine
Department of Surgery, Hamamatsu Rosai Hospital³⁾

A case of benign liver tumor in a 26-year-old Japanese woman who had taken oral contraceptive for about 5 years is reported. She had complained of low grade fever and right hypochondrial pain. Preoperative examination showed several hypoechoic tumors in the right posterior segment of the liver and a large hemorrhagic tumor in the medial segment. The latter was resected and the surgical specimen was examined pathologically. Macroscopically, the tumor was encapsulated by fibrous capsule, and occupied by hemorrhagic and necrotic mass. Histologic examination demonstrated remniscence of the trabecular pattern of tumor cells which resembled normal hepatic cord. No cellular atypism or capsular invasion was observed. Furthermore, portal triad was not recognized in the tumor. Both macroscopically and microscopically, cirrhotic or hepatitic change was absent in the non-tumorous part of the liver. These findings are compatible with those of hepatocellular adenoma. The postoperative course was uneventful, and the residual tumors in the right posterior segment have become reduced in both size and number, perhaps because of the withdrawal of oral contraceptive.

Key words
hepatocellular adenoma, oral contraceptive

Reprint requests
Keiji Maruyama Second Department of Surgery, Hamamatsu University School of Medicine
3600 Handa-cho, Hamamatsu-city, 431-31 JAPAN

Accepted
July 7, 1993

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