Experimental Studies Concerning about the Effects of the Partial Portal Arterialization-The Results of Long Time Observation upon the Hepatic Artery Ligated Liver-

Kiyotaka Ito

Second Department of Surgery, Hokkaido University, School of Medicine

Partial portal arterialization to prevent hepatic insufficiency under obstruction of hepatic arterial infiow was studied for a week in 21 mongrel dogs that were divided into three groups. The first group underwent only hepatic arterial ligation, and was observed for 48 hours (HAL). The second group underwent partial portal arterialization after ligation of the hepatic artery, and was observed for 48 hours (PPA-S). The third group treated like the second group, and was observed for a week (PPA-L). Each group consisted of 7 dogs. Total hepatic blood flow decreased to about 60% 48 hours after hepatic arterial ligation in the HAL group, but was maintained above the preoperative value in both the PPA-S and PPA-L groups. Portal venous pressure did not change in any group. Hepatic oxygen delivery decreased to 49% in the HAL group after 48 hours, whereas it could be maintained in the PPA groups even after a week. Hepatic oxygen consumption did not change significantly in any group. In the PPA-L group, GOT and GPT were not elevated as in the HAL group, and they recovered to the preoperative level after a week. In light microscopy, a marked necrotic change was noted in the HAL group, but no change was noted in the PPA groups. In conclusion, this experimental study showed that partial portal arterialization has beneficial effects on liver under hepatic artrial obstruction for at least a week.

Key words
partial portal arterialization, liver ischemia, oxygen metabolism of liver, histological change of liver

Reprint requests
Kiyotaka Ito Second Department of Surgery, Hokkaido University School of Medicine
N-14, W-5, Kitaku, Sapporo, 060 JAPAN

Accepted
July 7, 1993

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