Expression of a Novel Cancer Antigen Coagulant Cancer Antigen 1 on Colorectal Cancers

Haruhiko Inufusa, Toshiyuki Adachi, Masato Nakamura, Katsuhisa Shindo, Masayuki Yasumtomi

The First Department of Surgery, Kinki University School of Medicine

The cancer specific antigen coagulant cancer antigen 1 (CCA-l) is a novel serine protease that has a srong potential to activate Factor X directly. The monoclonal antibody AI18, which recognizes CCA-1 and has a specific inhibitory effect on CCA-I coagulant activity, was used for the immunohistological detection of CCA-1 on colorectal cancer tissues, and for comparison to CEA expression. CCA-1 expression on colorectal cancers was detected in 92% of the patients, while CEA was found in 98% of patients. Expression of CCA-1 on normal colorectal tissues was not observed, hence CEA was expressed in 72% of patients. Half the cases of colorectal adenoma and cancer in-adenoma showed positive CCA-1 expression. CCA-1 expression was observed partially on squamous epithelial cells, gastric glands and bronchial mucoglands of normal adults and fetuses. CCA-I is a novel cancer-specific antigen with well-characterized biological activity.

Key words
colorectal cancer, coagulant cancer antigen 1, immunohistological staining, unbalanced haemostasis in cancer, direct factor X activator

Reprint requests
Haruhiko Inufusa The First Department of Surgery, Kinki University School of Medicine
377-2 Ohonohigashi, Osakasayama, 589 JAPAN

Accepted
July 7, 1993

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