ORIGINAL ARTICLE
Clinicopathological Study of Mucinous Adenocarcinoma of the Stomach
Masatoshi Kawamura, Tohru Sato, Hidefumi Tsushima, Takashi Yokokawa, Kenji Marumori, Masaichi Iseki, Tsuyoshi Suzuki, Hideaki Kobayashi, Nobuo Komatsu, Koichi Takamura, Kazushige Arai, Mitsuo Kusano
Department of Surgery, Showa University School of Medicine
The clinicopathological features of 61 patients with mucinous adenocarcinoma of the stomach (MAC) were compared with those of 748 patients with nonmucinous adenocarcinoma (NAC) as a control. Findings in MAC patients included large size, location in all areas of the stomach, infiltrative growth, deep invasion, positive lymphnode metastasis, peritoneal dissemination and low incidence of resectability for cure, compared with those in NAC patients. The 5-year survival rate in MAC patients of stage III, IV was lower than that of well differentiatedadenocarcinoma. Histologically, MAC were divided into well differentiated and poorly differentiated types. Inpatients with poorly differentiated MAC, the age of onset was younger, the sex was tended to be female, the tumorwas more often located in the middle third of the stomach, tumor growth was infiltrative, and there was moreperitoneal dissemination. In patients with advanced gastric cancer, AgNORs L.I. in MAC (6.76±1.44) was significantly larger than that in either undifferentiated adenocarcinoma (6.01±0.88) or well differentiated adenocarcinoma (5.21±1.38) of the stomach (p<0.01, 0.05).
Key words
mucinous adenocarcinoma of the stomach, histological subtype of mucinous adenocarcinoma, AgNORs
Jpn J Gastroenterol Surg 27: 10-16, 1994
Reprint requests
Masatoshi Kawamura Department of Surgery, Showa University of Medicine
1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142 JAPAN
Accepted
October 13, 1993
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