An Experimental Study on the Mechanism of Activated Neutrophil Mediated Liver Injury

Makoto Odaka

First Department of Surgery, The Jikei University School of Medicine

The present study was designed to determine the mechanism of neutrophil-mediated liver injury in guinea pigs. Both serum GOT and GPT levels were significantly increased after transportal granulocyte colonystimulating factor (G-CSF) administration, and pathohistological examination revealed neutrophil infiltrates in the liver. The elevation of both serum GOT and GPT levels was attenuated in neutropenia induced by the administration of cyclophosphamide (CTX). Pretreatment by prostacyclin and thromboxane inhibitor significantly improved neutrophil-mediated liver damage. These results suggest that liver injury after G-CSF administration is caused by activated neutrophils and that prostacyclin and thromboxane inhibitor have a cytoprotective effect on neutrophil-mediated liver injury.

Key words
granulocyte colony-stimulating factor, prostacyclin, thromboxane inhibitor, neutrophil, liver injury

Reprint requests
Makoto Odaka First Department of Surgery, The Jikei University School of Medicine
3-25-8 Nishishinbashi, Minatoku, Tokyo, 105 JAPAN

Accepted
October 13, 1993

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