Analysis of Carcinogenesis by Identification of Abnormalities of Oncogene and Suppressor Oncogene and Pathological Features -A Case of Juvenile Multiple Colon Cancers-

Koh Miura, Kenichi Shiiba, Seiki Matsuno, Takayuki Masuda*, Masahiro Saito**

The First Department of Surgery and the Second Department of Pathology*, Tohoku University School of Medicine
The First Department of Pathology, Akita University**

A 21-year-old woman was admitted because of ileus after appendectomy, and an emergency operation was performed. Laparotomy revealed transverese colon cancer and metastasis to the left ovary, and right hemicolectomy and left oophorectomy was carried out. After 9 months, rectal cancer, sigmoid cancer and cancer polyps were diagnosed, and total colectomy was performed. The pathological features included moderately and well differentiated adenocarcinomas, and mucinous carcinoma. The immunohistochemical staining of p53 protein and the point mutation of K-ras oncogene codon 12 and exons 5, 7 , 8 of p53 suppressor oncogene were detected in the tumors, The results showed that there were various patterns of abnormal genetic changes. From these results, we consider this patient to have several patterns of carcinogenesis. The detection of changes in the genetic patterns of the surgical specimens will become more important for the analysis of the carcinogenesis including cancers of the digestive systems.

Key words
sporadic multiple colon cancers, p53 gene, K-ras gene

Reprint requests
Koh Miura First Department of Surgery, Tohoku University School of Medicine
1-1 Seiryo-machi, Aoba-ku, Sendai, 980 JAPAN

Accepted
October 13, 1993

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