A Case of Composite Tumor Consisting of Endocrine Cell Carcinoma and Tubular Adenocarcinoma at the Papilla Vater

Masami Mitani, Makoto Kataoka, Yoshiyuki Kuwabara, Yasuyuki Kureyama, Hiroshi Iwata, Akira Masaoka

The Second Department of Surgery, Nagoya City University Medical School

A 59-year-old man suffered from carcinoma at the papilla vater which resected by pancreatoduodenectomy. Histopathologically, the tumor showed areas of endocrine cell carcinoma and tubular adenocarcinoma. The specimen was studied by Grimelius' stain, Fontana-Masson's stain and immunohistochemical stain for NSE, Leu7, chromogranin and CEA. The tumor was positive for Grimelius' stain and Leu7 in both areas, and for chromogranin and NSE only in the area of adenocarcinoma, suggesting the same origin of the two components. Furthermore, the neuroendocrine chatracters are expressed not at the area of endocrine cell carcinoma but at the area of adenocarcinoma.

Key words
composite tumor, endocrine cell carcinoma, papilla vater

Reprint requests
Masami Mitani The Second Department of Surgery, Nagoya City University Medical School
1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, 467 JAPAN

Accepted
December 8, 1993

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