The Treatment of Liver Metastasis and Peritoneal Dissemination of Gastric Cancer

Youichi Kitamura, Hiroyoshi Suzuki, Tsuyoshi Sasagawa, Kiyotaka Yamamoto, Yuuko Takaishi

The Institute of Gastroenterology Tokyo Women's Medical College

The treatment of liver metastasis and peritoneal dissemination of gastric cancer was studied. Concomitant hepatectomy for liver metastasis had littel effect on the survival rate, but tramscatheter arterial chemoembolization therapy was effective for liver metastasis. In the case of drug treatment, the effect of adriamycin Lipidol emulsion was enhanced when it was combined with the surfactant lecithin. Intra-aortic administration of anticancer agents to reach the peritoneum via the lumbar arteries was studied for the treatment of peritoneal dissemination. In the normal peritoneum, the intra-aortic administration of drugs produced higher concentrations than intravenous administration. When peritoneal dissemination was induced experimentally, about the same effect of drugs were achieved by intraperitoneal and intra-aortic administration. Histological examination also showed a better antitumor effect in the intra-aortic group.

Key words
liver metastatis of gastric cancer, peritoneal dissemination of gastric cancer, treatment of stage IV gastric cancer

Reprint requests
Youichi Kitamura The Institute of Gastroenterology, Tokyo Women's Medical College
8-1 Kawadacho, Shinjuku-ku, Tokyo, 162 JAPAN

Accepted
December 8, 1993

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