Studies on Wound Healing of the Anastomosis between Pancreas and Gastrointestinal Tract in Dogs by Microangiography and Histopathological Findings

Kiyotaka Fukura, Takashi Aikou, Sonshin Takao, Hiroyuki Shinchi, Hisaaki Shimazu

First Department of Surgery, Kagoshima University School of Medicine

This study was performed in order to investigate what kind of anastomosis, between pancreas and gastrointestinal tract, is ideal from the view of wound healing. Pancreaticogastrostomy, pancreaticojejunuostomy, and invagination of the pancreas into the stomach in 36 mongrel dogs were performed and wound healing was studied by microangiography and histopathology on the 3rd, 5th, 7th and 14th postoperative days. Avascular areas and neovascular vessels in microangiographic findings, and necrosis, bleeding, acute inflammatory cell infiltration and collagen in histopathological findings were evaluated. There is little difference between pancreaticogastrostomy and pancreaticojejunostomy in microangiography and histopathology. The avascular area of invagination of the pancreas into the stomach was smaller than that of the others. The patency of the pancreatic duct on the 14th postoperative days was examined, and histopathological findings of the pancreatic remnant were studied. One case of pancreaticogastrostomy and one of invagination of the pancreas into the stomach had stenotic pancreatic ducts, and the pancreas showed severe fibrosis. These results suggest that invagination of the pancreas into the stomach has less wound of the anastomotic site compared with the other procedures, but patency of the pancreatic ducts may be a problem.

Key words
wound healing, pancreaticogastrostomy, pancreaticojejunostomy, invagination of the pancreas into the stomach, microangiography

Reprint requests
Kiyotaka Fukura First Department of Surgery, Kagoshima University School of Medicine
8-35-1 Sakuragaoka, Kagoshima, 890 JAPAN

Accepted
April 13, 1994

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