Prediction of Postoperative Organ and Lymph Node Recurrences in Esophageal cancer

Takao Saito¹⁾, Kiyone Chikuba²⁾, Sinya Uchino²⁾, Kazutoshi Kaketani²⁾, Kaoru Etoh²⁾, Masaki Miyahara²⁾, Michio Kobayashi²⁾, Motonosuke Furusawa¹⁾

¹⁾Department of Gastroenterological Surgery, National Kyushu Cancer Center
²⁾First Department of Surgery, Oita Medical University

In an attempt to preoperatively predict organ and lymph node recurrence after radical resection of esophageal cancer, risk factors associated with these recurrences were studied. Twelve factors consisting of hst-1 amplification, DNA ploidy, DNA index, stemline heterogeneity (HG) and 8 known clinicopathological prognostic factors were analyzed in 77 patients with thoracic esophageal cancer using univariate and Cox's multivariate analyses. Amplification of hst-l, histology and skip lesion were statistically significant as independent risk factors for organ recurrence, while HG and skip lesion were factors for lymph node recurrence. By analyzing combinations of these factors, the incidence of organ recurrence was found to be 71% when hst-1 amplification was positive and the histology was a poorly differentiated squamous cell carcinoma, an undifferentiated carcinoma or other histologic types. Amplification of hst-1 and HG were accurately measured in biopsy specimens from most patients. Thus, as far as organ recurrence is concerned, a combination of two risk factors, hst-1 amplification and histology, may be preoperatively predictive of this recurrence following radical resection of esophageal cancer.

Key words
hst-1 amplification, DNA stemline heterogeneity, postoperative recurrence of esophageal cancer

Reprint requests
Takao Saito Department of Gastroenterological Surgery, National Kyushu Cancer Center
3-1-1 Natame, Minamiku, Fukuoka, 815 JAPAN

Accepted
July 6, 1994

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