Study on Safety and Finding of Direct Effect of Preoperative Cisplatin and 5-Fluorouracil Combination Chemotherapy in Intensive Treatment for Esophageal Carcinoma

Junji Minamide, Hiroyoshi Koizumi, Norio Aoyama, Yukihiro Ozawa, Makoto Tokunaga, Fumiyasu Fukano, Ryouta Moriwaki

First Division of Surgry, Kanagawa Cancer Center

We have investigated safety and finding of direct effect of preoperative Cisplatin and 5-Fluorouracil combination therapy (in the following it is abbreviated to CDDP+5FU therapy) in intensive treatment for esophageal carcinoma. Thirty-two patients were recieved CDDP+5FU therapy before operation were selected for this study from 85 patients with esophageal carcinoma who underwent surgery from September, 1991 to August, 1993. 80 mg/m² (day 1) of Cisplatin and 800 mg/m² (day 1-4) of 5-Fluorouracial were administered for 3 weeks as one course. Operation was performed to patients who showed no change or less and second course was treated to those who showed partial responce. Side effects were mild and did not affect operation schedule and postoperative progress. Partial responce in 11, no change in 17 and progresive disease in 4 were observed by image diagnosis. Histopathological diagnosis indicated slight effect or above in 18 (56%). Slight effect or above on lymph nodes were observed in 7 (28%). Preoperative CDDP + 5FU therapy had mild side effects and did not affect postoperative condition. Its effect on lymph node was also good.

Key words
neoadjuvant chemotherapy for esophgeal carcinoma, cisplatin and 5-fluorouracil combination chemotherapy, side effects of chemotherapy, histopathological examination

Reprint requests
Junji Minamide First Department of Surgery, Yokoyama City University
3-9 Fukuura, Kanazawa-ku, Yokohama, 241 JAPAN

Accepted
July 6, 1994

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