Tumor Angiogenesis in Gastric Carcinoma as an Indicator of Recurrence -Using Monoclonal Antibody Against Factor VII Related Antigen-

Kiyoshi Maeda, Yong-Suk Chung, Satoshi Takatsuka, Yoshinari Ogawa, Tetsuji Sawada, Naoyushi Onoda, Yasuyuki Kato, Yuichi Arimoto, Atsunori Nitta, Michio Sowa

First Department of Surgery, osaka city university Medical School

The expression of factor VIII related antigen (FVIII-RAg) was investigated by immunohistochemical study of 124 gastric cancer patients to determine the correlation between the tumor's angiogenesis and the clinicopathological factors and the prognosis. The distribution of the microvessels was divided into the intratumoral type and the stromal type. Involvement of veins and liver metastasis were more often observed in patients with the intratumoral type. Patients with the intratumoral type tended to have a worse prognosis than patients with the stromal type. According to the site of recurrence, liver metastasis was significantly (p<0.01) more common in patients with the intratumoral type than those with the stromal type. Otherwise, patients with the stromal type tended to have the recurrence in the peritoneum. As a result of this study, we conclude that the intratumoral type is associated with blood-borne metastasis and that examination of the distribution of microvessels may be useful as a predictor of the site of recurrence.

Key words
angiogenesis, factor VIII related antigen, gastric cancer, recurrence

Reprint requests
Kiyoshi Maeda First Department of Surgery, Osaka City University Medical School
1-5-7 Asahimachi, Abeno-ku, Osaka, 545 JAAPN

Accepted
June 8, 1994

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