Experimental Studies on Liver Energy Metabolism and the Hepatic Haemodynamic Response to Normothermic Portal Venous Flow Reductions

Yoshifumi Katagiri, Hajime Hirose, Shoushi Senga, Masatoshi Hayashi, Hirokazu Matsutomo, Hideo Itou, Naoki Imai, Tatsumi Iida, Masatomo Hayashi, Atsuyoshi Onitsuka*

First Department of Surgery, Gifu University School of Medicine
*Kaizu Medical Association Hospital

Changes in liver circulation and liver energy metabolism during acute reduction in portal venous blood flow were studied in dogs. Extracorporal circulation from the superior mesenteric vein to the portal vein during total clamping of the hepatoduodenal ligament was constructed to enable varying degrees of portal flow by a roller pump. Mongrel dogs were divided into three groups by the rate (100%, 50%, 25%) of portal perfusion (PP). 1) In the 100% flow group (n=6), oxygen delivery (OD) was reduced because of clamping the hepatic artery, but it was compensated by an increase in the oxygen extraction rate (OER). ATP in the liver was not changed significantly during PP. 2) In the 50% flow group (n=6), OD was reduced because of clamping the hepatic artery and portal venous flow reduction. OER was increased. ATP at 120 minutes' PP was significantly lower than the previous level. However, arterial ketone body ratio (AKBR) was more than 0.25 during PP.3) In the 25% flow group (n=6), OER was significantly higher than that in the l00yo flow group at 15 and 30 minutes. However, OER at 120 minutes' PP was significantly lower than that at 60 minutes' PP. ATP at 60 minutes' PP was significantly lower than that in the 100% flow group. AKBR in 1/6 (at 60 minutes), 2/6 (at 90 minutes) and 4/6 (at 120 minutes) were less than 0.25. Portal vein resistance was significantly higher than that in the 100% and 50% flow group at 60, 90 and 120 minutes. These results suggested that normal metabolism could not be maintained in the 25% flow group after 60 minutes' PP, and become abnormal, as indicated by ATP and AKBR.

Key words
portal vein bypass, hepatic energy metabolism, hepatic circulation, portal vein flow reduction

Reprint requests
Yoshifumi Katagiri First Department of Surgery, Gifu University School of Medicine
40 Tsukasa-cho, Gifu-shi, 500 JAPAN

Accepted
June 8, 1994

To read the PDF file you will need Abobe Reader installed on your computer.