A Case of Collison Tumor with Squamous Cell Carcinoma and Malignant Lymphoma in the Cardia

Shin-ichi Murakami, Yuzo Uchida, Nobuhiro Kubo, Yoshinori Hiraoka, Thuyoshi Noguchi, Katsuhiko Matsumoto, Tetsuo Hadama, Toshio Fujioka*, Shigeo Yokoyama**

Second Department of Surgery, Second Department of Internal Medicine*, Oita Medical University, Division of Pathology, Central Diagnotic Laboratory**, OIta Medical University Hospital

A 73-year-old woman visited the Oita Medical University Hospital with a complaint of dysphagia. Esophagectomy and total gastrectomy were performed. The patient was alive 51 months after the operation without any sign of recurrence. Pathological examination of the resected specimen showed a Borrmann type-2 lesion measuring 5.0×5.0 cm and a IIc lesion measuring 10.9×9.0 cm located close to each other in the cardia of the stomach. Microscopic examination revealed a collison tumor consisting of poorly differentiated squamous cell carcinoma and malignant lymphoma. The serial sections showed that there was no histological transition between the two components. With respect to metastatic sites in the lymph nodes, only one component from each tumor was seen. The constituent cells of the squamous cell carcinoma demonstrated positive immunoreactivity for keratin and EMA. Lymphoma cells showed positive immunoreactivity for LCA. Thus, the histological findings of the two tumors confirmed a collison tumor.

Key words
collison tumor, squamous cell carcinoma of the esophagus, malignant lymphoma of the stomach

Reprint requests
Shin-ichi Murakami The Second Departmet of Surgery, Oita Medical University
1-1 Idaigaoka, Hasama-machi, Oita, 879-55 JAPAN

Accepted
September 14, 1994

To read the PDF file you will need Abobe Reader installed on your computer.